The first wounds on the constitution were in 1913 with the 16th and 17th amendments ... which came about because of the rise of the Progressive movement and the Wilson presidency.
If you don't buy that (since you are establishing the line as "limits placed on government") then the first wound was 1919 with the passage of the 18th amendment (which used the constitution to limit the rights of the people instead of the power of the government for the first time).
My only point is that America has been infected with the disease of the left for longer than people realize. At this point the damage is what it is so it's somewhat academic to argue when the first wound was inflicted.