Anyone hunting with a 16" AR15 with a suppressor?

[Storm]

... and the first shot can be inaccurate. Also heard that there is substantial noise from the chamber along with the gas.

Adding the can will change your POI, but the precision should be consistent, if not improved. Re-zero the gun with the can on it. Write down the difference in elevation and windage/azimuth settings, so you can re-zero the sight(s) on the fly, when you are swapping the can on/off.

Yea, you will get some extra noise from the breach as the gun cycles. This happened on my .22LR, which bugged me, but I was going for uber-quiet with that round. I ended up getting a bolt-action. With a super-sonic rifle round, there's going to be noise either way.