On a motorcycle? Take US 40. I-80 will make you want to kill yourself.
EDITED TO ADD: Actually I-80 isn't that terrible if you haven't done it a lot. I have which is why I avoid it but if you haven't done it before, it can be somewhat interesting. Once you get past Elk Mountain near Arlington (about 50 miles West of Laramie) the scenery doesn't change for 300 miles. 300 miles of flat, featureless desert (though having said that, it's still not as bad as SA or Kuwait.)
The big thing to watch out for is wind. If it is going to be windy, take a different route. The winds can be horrible on I-80 because there's no terrain to stop them.
I last did I-80 on a motorcycle in 2015. I did a SS1000 (Saddlesore 1000 ride, 1000 miles in <24 hours.) We started in Denver, rode I-70 to Green River, UT, then took US 6 up to Provo, then rode up to I-80 and took that all the way back to Cheyenne and then down to Denver. Took about 18 hours.
If you're trying to make time, 80 is the best way to go, again, unless there are high winds forecasted. If that's the case, take US 40 which is 100x more scenic anyway.