While my initial instinct is to bug out, the reality is that's probably a very dangerous decision if you're trying to get out with the rest of the masses clogging up the roads. Hunkering down in my house till the dust has settled is probably the best bet since I've got kids and all my supplies are here. If it's disease or a natural disaster that doesn't make my home toxic, then staying put is the best plan. If the metro area gets nuked or what not, then it doesn't matter since I'll probably be dead or dying.