I would sight in for 100 for normal hunting conditions. With quality ammo, gun combo and depending on your skills you can go a long damn way down range. Unless your looking for trouble most shots will be inside of 200yds, but check you tube and longrangehunting.com if you are interested, I do not advise this silly stuff unless you know what you are doing! But the 308 is a 1k round IMO, "effective kill range" 850, "effective target range" 1100 depending on ammo. Most factory match ammo I have ran is good for 900-950, hunting ammo falls way short of that. I have seen it kill at over 1k in the hands of a pro, but not elk.