Accuracy sucks, so that's out of the question. The .22 LR is a good penetrator, so that's about the only thing going for it. If it hits sideways and is unstable in flight, penetration is also going out the window.

A 9mm would be leaps and bounds more effective and I'd prefer to imagine the nasty impact of a 230gr .45 JHP at 900fps that goes exactly where it's supposed to.