The results of the ballistic testing in The Thompson-LaGarde Cadaver Tests of 1904:

Based upon the data they gathered, Thompson and LaGarde stated, "the Board was of the opinion that a bullet, which will have the shock effect and stopping effect at short ranges necessary for a military pistol or revolver, should have a caliber not less than .45". But they also said, "...soldiers armed with pistols or revolvers should be drilled unremittingly in the accuracy of fire" because most of the human body offered "no hope of stopping an adversary by shock or other immediate results when hit."