coyote caliber?

[One Shot]

Do you have a place to hunt them? That seems to be the hard part. I think all the calibers you suggest would work, 22-250 or .223 is what I would use.

[DSB OUTDOORS]

I have a couple of AR's I put together in .223 WSSM and my favorate.
.243 WSSM distance and knock down power!!

[sdavis4]

I use a .270 but I have also heard a 30-30 works well. But you can't go wrong with the .223. Happy hunting

[glennski]

I'm a fan of the 220 swift and 17 fireball

[bruceleroy]

Any 20 caliber bullet with good velocity will floor them. I do like the .50 BMG suggestion...

[buckshotbarlow]

6x45 or 6xc get my vote

[katodevil]

I use T-shot 3 1/2" 12 gauge for the close shots, good to about 70 yards, and AR 5.56 for everything else of course